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Mitochondrial
Berberine
Also known as: Berberine HCl
Moderate Evidence89+ human studies
Often called "natural metformin". Activates AMPK, improves insulin sensitivity, and has demonstrated cardiovascular benefits in multiple RCTs.
Mechanism of Action
AMPK activator → mimics caloric restriction signalling. Modulates gut microbiome. Inhibits PTP1B (insulin sensitisation).
Dosage & Timing
Dose
500mg 2–3x/day with meals
When to take
With meals (GI tolerance)
Stacks Well With
Caution
May interact with: metformin, blood-sugar-medications
Evidence Scores
Evidence Quality
B0/100
Safety Profile
A0/100
Popularity
A0/100