27 articles

Supplement Reviews

Evidence-based reviews of longevity supplements, researched from published studies.

Urolithin A (Mitopure): Trials, Funding and Cost per Dose

Urolithin A human trials: missed primary endpoints, company funding, and what three brands cost per month at the dose used in the trials.

Longevity Intel editorial4 min read

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Glycine for Sleep: What the Trials Show and What It Costs

Glycine before bed: the small trials behind the claim, their sample sizes and funding ties, the dose they used, and a cost check against Thorne's price.

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Longevity Supplements With Null Trials: Evidence Ledger

Longevity supplements where the best human trials found no benefit: the claim, the strongest trial or review, the result and a grade for each.

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Third-Party Tested Supplements: NSF, USP, IFOS Compared

What NSF Certified for Sport, USP Verified, Informed Sport and IFOS check, what they cannot prove, and which of 44 brand products state each.

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Curcumin: Arthritis Trials, Not Longevity

Curcumin: a meta-analysis of 29 RCTs found improved pain and inflammation in arthritis, with low-quality trials; no evidence it extends life.

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Lithium Orotate and NDGA: What Is Actually Known

Lithium orotate: a 2025 Nature study links brain lithium loss to Alzheimer's in mice and human tissue; no human supplement trial. NDGA not covered.

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Alpha-Lipoic Acid: Neuropathy Evidence, Limits

Alpha-lipoic acid: a meta-analysis of 10 RCTs found it reduced symptoms in diabetic neuropathy, but no trial supports a longevity claim.

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Berberine vs Metformin: What Trials Compare

Berberine vs metformin: one 36-person pilot found similar glucose lowering; metformin is a prescription drug and neither is proven to extend life.

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Resveratrol and Pterostilbene: Trial Evidence

Resveratrol from human data: no link to mortality in older adults, better glucose control only in people with diabetes, and no trial for longevity.

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Taurine for Longevity: Animal Data vs Human Trials

Taurine's 2023 Science paper was mostly animal work; a 2026 meta-analysis of 34 human RCTs found lower glucose and triglycerides. Evidence and cost.

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Collagen Supplements: Skin Evidence and Limits

Collagen supplements: a review of 10 publications found skin benefits; evidence for joints, bones or longevity is not shown here.

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Gut Health and Longevity: Probiotic Evidence

Gut microbiome interventions: a 2026 meta-analysis of 14 studies found better cognition scores in older adults, with heterogeneity; no lifespan evidence.

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Lion's Mane Mushroom: Human Trial Evidence

Lion's mane (Hericium erinaceus): a 2025 review found only 5 RCTs, small and short, with limited safety data. What is and is not shown.

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Metformin for Longevity: What Is and Is Not Proven

Metformin and longevity: observational survival data in diabetes, no completed trial of aging outcomes, and why it is a prescription drug for a doctor.

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NAD+ Boosters: What Human Trials Show

NAD+ precursors (NMN, NR) and IV NAD+ vs the human evidence: blood levels rise, functional results are mixed, IV NAD+ has no anti-aging outcome trials.

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Peptides for Longevity: What Human Evidence Exists

Peptides such as BPC-157: a 2025 review found 35 preclinical studies and one clinical study; FDA has not approved BPC-157. Information only.

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Quercetin and Fisetin: Senolytic Claims vs Trials

Quercetin and fisetin as senolytics: human trials tested dasatinib plus quercetin in patients, not supplements for healthy aging.

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Rapamycin for Longevity: Human Evidence, Mouse Data & Risks

A source-led review of sirolimus and rapalogs: replicated mouse lifespan findings, limited human ageing studies, approved uses, safety warnings

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CoQ10 and Ubiquinol: What Trials Show, and Cost

CoQ10 evidence: Q-SYMBIO in heart failure patients, mixed statin-muscle-pain meta-analyses, ubiquinol vs ubiquinone, and monthly cost at the trial dose.

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Spermidine: Observational Link, Null Trial

Spermidine's lower-mortality link is from a food-questionnaire cohort; the best supplement RCT (SmartAge, 100 adults, 12 months) found no memory benefit.

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Ashwagandha: Stress and Sleep Evidence, Safety

Ashwagandha in two meta-analyses: lower anxiety and stress scores in 12 trials, a small sleep effect in 5, high heterogeneity and limited safety data.

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Berberine: Blood Sugar Trials, Side Effects

Berberine evidence: a meta-analysis of 46 trials in type 2 diabetes, how it compared with metformin in a small pilot, side effects, and what is unproven.

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Creatine for Longevity: Evidence, Forms, Cost

Creatine monohydrate from meta-analyses: muscle, memory and bone in older adults, kidney and hair concerns, and monthly cost at a trial dose.

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Magnesium Supplements: Evidence by Form, and Cost

Magnesium from trials and meta-analyses: blood pressure, sleep in older adults, the L-threonate memory trial, and monthly cost at the dose a review used.

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NMN: Legal Status, NMN vs NR, What Trials Show

Is NMN legal in the US supplement market, how does it compare with NR, what human trials found, and what a month costs at the dose those trials used.

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Omega-3 Fish Oil: What Trials Show, Cost per EPA+DHA

Omega-3 fish oil from the big trials: VITAL, REDUCE-IT and STRENGTH results, the atrial fibrillation signal, and monthly cost at the dose VITAL used.

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Vitamin D3 + K2: What the Evidence Supports, and Cost

Vitamin D3 and K2 (MK-7) from trials and guidelines: who benefits, what large trials found, safety limits, and monthly cost at the dose used in a trial.

5 min readRead article

Related tools for supplements

Complete stackTiered dosing framework Evidence database68+ compounds by evidence level NMN vs NRNAD+ precursor matchup Top 10 overallEvidence-ranked list

Cost per study dose

What 12 supplements cost per month at the dose used in a cited human study, across 35 products, with the third-party testing each brand states. Context for comparing prices, not dosing advice.

Open the cost per study dose table