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Urolithin A (Mitopure): Trials, Funding and Cost per Dose

Urolithin A human trials: missed primary endpoints, company funding, and what three brands cost per month at the dose used in the trials.

LLLongevity Intel editorialPublished Updated 3 min read

Researched from published studies and manufacturer specifications, checked .

We have not tested products ourselves. How we research

Quick verdict

Urolithin A has small human trials, all sponsored by the maker of Mitopure; two missed their primary endpoints. At the 1,000 mg/day used in two trials it costs $198 a month as Timeline's Mitopure bought once ($178 on monthly delivery), $138 as Omre and about $90 as Mt. Angel, but only Mitopure is the trial material.

Talk to your doctor first. This is general information, not medical advice. Supplements and devices can interact with medicines and health conditions. We quote study protocols for context and do not recommend doses.

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Trial ingredient

Timeline Mitopure Softgels (vegan)

Timeline · $99 for 60 softgels, $89 on monthly delivery (brand page, 29 Sept 2026)

Price as of July 2026. Check the retailer for the current price and availability.

Pros

  • Uses the Mitopure ingredient the trials used, per Timeline and the trial papers
  • Brand states NSF Certified for Sport on the product page

Cons

  • $198 a month bought once, or $178 on monthly delivery, at the 1,000 mg/day dose used in two trials
  • The trials are tied to Amazentis, the developer of the Mitopure ingredient
View product

The short answer: urolithin A has several small human trials, but the headline claims rest on secondary results and every trial we read is tied to Amazentis, which makes the Mitopure ingredient. In 66 older adults the primary endpoints (6-minute walk and muscle ATP) did not significantly improve; in middle-aged adults muscle strength rose about 12% but the primary endpoint, peak power, did not. At the 1,000 mg a day used in two trials it costs about $198 a month as Timeline’s Mitopure bought once ($178 on monthly delivery), $138 as Omre and $90 as Mt. Angel (brand pages, 29 Sept 2026). Talk to your doctor before starting.

What the trials show

Grades follow the rubric; overall grade: Emerging.

TrialWho and whatPrimary endpointOther findingsTies
Liu 2022, JAMA Netw Open66 adults aged 65 to 90; 1,000 mg/day or placebo for 4 months6-minute walk distance and maximal muscle ATP: no significant improvementMuscle endurance improved at 2 months (secondary); lower acylcarnitines, ceramides and C-reactive proteinAuthors affiliated with Amazentis
Singh 2022, Cell Rep MedMiddle-aged adults; two doses for 4 monthsPeak power output: not significantly improvedMuscle strength up about 12%; aerobic endurance and 6-minute walk improvements described as clinically meaningful; lower C-reactive proteinAmazentis sponsored; several authors employees or board members
Denk 2025, Nat Aging50 healthy middle-aged adults; 1,000 mg/day or placebo for 4 weeksT cell changes: naive-like CD8+ cells up 0.50 percentage points (CI 0.16 to 0.83) and CD8+ fatty acid oxidation capacityImmune markers, not illness or infection outcomesAmazentis funded it and supplied Mitopure; employees among authors

What the trials do not show: any effect on lifespan, disease risk or long-term safety. Nothing here compares urolithin A with exercise, which is the established way to build muscle and fitness.

Cost per month at the 1,000 mg/day trial dose

Two trials above used 1,000 mg a day (Liu 2022 and Denk 2025). This is a price comparison, not a recommendation of any amount. Prices from brand pages on 29 Sept 2026, before tax, shipping and subscription discounts; our arithmetic.

ProductPrice and pack500 mg/day1,000 mg/dayTesting stated by the brand
Timeline Mitopure Softgels$99 once, or $89 on monthly delivery; 60 softgels (500 mg per 2)$99 ($89 on delivery)$198 ($178 on delivery)NSF Certified for Sport; Mitopure ingredient
Omre Urolithin A$69, 30 servings of 500 mg (2 capsules)$69$138Batch testing for potency, purity and contaminants, naming Intertek and Health Level One; not Mitopure
Mt. Angel Vitamins Urolithin A$89.99, 60 capsules of 500 mg$45.00$89.99“Tested & Verified” stated; no lab or certifier named on the page

Timeline’s page data lists $99 for a one-time purchase and $89 for monthly delivery (the plan is named 1-month supply delivered monthly); Omre’s own page claims Timeline costs $125 a bottle, which does not match Timeline’s page. Omre also lists $65.55 on subscription. Check the checkout price. The Cell Rep Med abstract does not state its doses, so we price only the two trials that do. For comparison, creatine has far more evidence for muscle, at a fraction of the price; none of the urolithin A trials we read was independent of the maker. The full cost per study dose table covers 12 compounds.

Where it fits

See urolithin A in the graded supplement ladder, and the strength training protocol for the established way to build muscle. The complete stack shows sequencing.

The testing statements in the table range from NSF certification to unnamed labs; third-party testing explained.

Method note

Researched from PubMed abstract records and three brand pages, checked 29 Sept 2026. Abstracts only; grades are our judgement using the published rubric. We did not test any product. Longevity Intel earns a commission on some links. General information, not medical advice.

Common questions

Does urolithin A work?

Trial evidence is mixed. In a 4-month RCT of 66 older adults (JAMA Netw Open 2022) the primary endpoints, 6-minute walk distance and muscle ATP production, did not improve significantly, though muscle endurance, a secondary endpoint, did. In middle-aged adults (Cell Rep Med 2022) muscle strength improved by about 12% but the primary endpoint, peak power output, did not significantly improve.

Who paid for the urolithin A studies?

Amazentis SA, which makes the Mitopure ingredient, sponsored the Cell Reports Medicine trial and funded the 2025 Nature Aging trial, providing the product; authors on both include Amazentis employees. The JAMA Network Open paper lists authors affiliated with Amazentis. Industry sponsorship does not make results false but raises the bar for independent replication.

Is cheaper urolithin A the same as Mitopure?

We found no trial of a non-Mitopure product, so we cannot say. Omre and Mt. Angel state 500 mg of urolithin A per serving and batch testing; none of the published trials used them.

Sources

Update log

  1. Independent audit: Timeline's $89 is its monthly-delivery price; the one-time price on the product page is $99, so the one-time cost at 1,000 mg/day is $198 ($178 on delivery). Removed an unsupported '20% price cut' line and the Omre-page figure for Timeline's bottle; Mt. Angel testing wording corrected.
  2. Added a three-brand cost-per-dose comparison (Timeline, Omre, Mt. Angel) at the 1,000 mg/day dose used in two trials, with testing statements. Corrected the sponsorship wording for the 2025 immune trial (Amazentis funded it and supplied Mitopure). Removed the stale dataset-label note.
  3. Sourcing pass: replaced the 'strongest human evidence' and 'four RCTs' claims with the three trials we could verify, their missed primary endpoints and their sponsor ties; added cost at the trial dose; removed unverified product claims and 'who should consider it'.

Data and comparisons

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